News & Events: CLOTT Study

UCSF trauma surgeon Lucy Kornblith, M.D. has been awarded a 5-Year $1M National Institutes of Health (NIH) K23, Mentored Patient-Oriented Research Award to study to post-injury platelet biology. The award, through the National Institute of General Medical Studies, will support Dr. Kornblith's research through 2023.  The grant titled "Post-Injury Platelet Biology: Mechanisms and Outcomes", supports translational patient-oriented research. Specifically, Dr. Kornblith will investigate causal pathways, mechanisms, and associated outcomes of altered post-injury platelet biology in a prospective [...]

The National Trauma Institute recently issued an update on the progress of CLOTT Study, a 2nd phase that will more closely investigate the role of platelet biology in post-traumatic pulmonary embolism. To that end, UCSF surgeon-scientist Lucy Kornblith, M.D. has been recruited by principal investigator M. Margaret "Peggy" Knudson, M.D., FACS.  Following a productive investigation of the incidence of pulmonary thrombi after injury and the role of clot breakdown in the development of post-traumatic pulmonary embolism, the CLOTT study group (Consortium of Leaders in the Study of Traumatic [...]

The CLOTT (Coalition of Leaders in Thromboembolism) study group, led by trauma surgeon M. Margaret "Peggy" Knudson, M.D., FACS, has begun enrolling patients in a landmark clinical trial looking at the treatment and prevention of post-traumatic pulmonary embolism. The study, which includes  investigators at 17 Level 1 trauma centers, is funded by a $4.25M grant from the Defense Medical Research and Development Program (DMRDP).  Dr. Knudson, the study's principal investigator, is a professor of surgery and member of the UCSF Department of Surgery at Zuckerberg San Francisco General Hospital [...]